Q) Which of the following is not a risk factor / least associated with small bowel adenocarcinoma?
a) Familial adenomatous polyposis (FAP)
b) Hereditary nonpolyposis colorectal cancer
c) Peutz-Jeghers syndrome
d) Juvenile polyposis coli
Correct Answer: d) Juvenile polyposis coli
Explanation:
Juvenile Polyposis Coli is least associated with small bowel adenocarcinoma.
Risk factors for Small Bowel Adenocarcinoma:
1. Hereditary polyps:
- Familial adenomatous polyposis (FAP)
- Hereditary nonpolyposis colorectal cancer
- Peutz-Jeghers syndrome
2. Inflammatory and metabolic:
- Crohn disease
- Gluten-sensitive enteropathy (celiac sprue)
- Prior peptic ulcer disease
- Cystic fibrosis
- Biliary diversion (e.g., previous cholecystectomy)
3. Lifestyle:
- Smoking
- Heavy alcohol use (>80 g/day ethanol)
- Red meat/salted food intake
4. Genetic:
- Kras
- 5q (APC gene)
- 17q (p53 gene)
- 18q
- DPC4
- SMAD4
- MSI-H (Microsatellite Instability-High)