Prognostic factor for carcinoma esophagus

Q. Most important prognostic factor for carcinoma esophagus is
 
a) Cellular differentiation                                 b) Depth of  esophagus involvement
 

c) Length of  esophagus involvement            d)   Age of the patient

B
Most important is depth of involvement of wall  of esophagus and lymph node involvement of the surrounding esophageal tissue.
 Length of esophagus involvement is not that important because esophagus has extensive submucosal lymph supply and for complete cure 10 cm excision margin would mean removal of almost total esophagus.

Summary of Key Prognostic Factors:

Factor Prognostic Impact
Depth of invasion Most important
Lymph node involvement Highly significant
Distant metastasis Very poor prognosis
Cellular differentiation Moderate significance
Tumor length and location Lesser importance
Patient age/health Indirectly affects prognosis
Treatment response Useful for tailoring therapy
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