Juvenile Polyposis Coli

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Juvenile Polyposis Syndrome MCQ | NEET SS Surgery
COLORECTAL SURGERY MCQ | NEET SS

Juvenile Polyposis Syndrome

A 12-year-old boy presents with recurrent episodes of painless rectal bleeding and anemia. Colonoscopy reveals multiple juvenile hamartomatous polyps throughout the colon. Which of the following statements regarding this syndrome is FALSE?

A. It may be associated with a SMAD4 mutation.
B. It is associated with an increased risk of gastrointestinal malignancy.
C. The polyps are most commonly located in the ileum.
D. It is inherited in an autosomal dominant pattern.

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Juvenile Polyposis Syndrome: Important Exam Notes

Juvenile polyposis syndrome is an inherited gastrointestinal polyposis condition characterized by multiple juvenile hamartomatous polyps. Patients may present with rectal bleeding, anemia, abdominal symptoms, or complications related to polyp burden.

Genetics and inheritance

The principal genes associated with juvenile polyposis syndrome include SMAD4 and BMPR1A. The syndrome usually follows an autosomal dominant inheritance pattern.

Malignancy risk

JPS is associated with an increased risk of gastrointestinal malignancy, particularly colorectal cancer. Gastric cancer risk may also be increased. Appropriate surveillance and specialist assessment are important parts of management.

NEET SS exam takeaway

When a question describes a child with recurrent rectal bleeding and multiple juvenile hamartomatous polyps, consider juvenile polyposis syndrome. Remember the association with SMAD4 and BMPR1A, autosomal dominant inheritance, and increased gastrointestinal cancer risk.

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