NEET SS Important Trials in GI & Onco Surgery

Q) Not true about Cross Trial?

a) Pathological response rate is more in SCC than Adeno CA

b) No change in overall survival

c) Grade III/IV hematological toxicity is less than 10%

d) No difference in overall morbidity and mortality between the two arms

Ans b ) At 45 months, the trial showed a significant survival benefit.

This is a Dutch trial which showed preop chemo RT followed by Surgery alone is better than upfront Surgery in patients with ca esophagus or GE junction tumors.

Both SCC and Adeno CA were included .Pathologic complete responses were seen in 24% of adenocarcinomas and 49% of squamous cancers ( a is true)

Options C and D are true

Ref Devita 

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