Sestamibi in Parathyroid

Parathyroid Sestamibi MCQ
Q) The sensitivity and specificity of sestamibi for parathyroid localization are reported to be 79% and 90%, respectively. Which of the following best describes a potential source of false positives in sestamibi imaging?
A) Parathyroid adenomas in patients with hyperparathyroidism
B) Thyroid nodules with high oxyphilic content, such as Hürthle cell nodules
C) Low mitochondrial content in thyroid tissues
D) Parathyroid glands in normal positions
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Primary Hyperparathyroidism

Primary Hyperparathyroidism MCQ - Free Question
Q) Which is not a feature of primary hyperparathyroidism?
a) Increase Parathormone
b) Increase Calcium
c) Decreased phosphate
d) Dystrophic calcification
Answer – Free

Answer: d) Dystrophic calcification

Explanation: Clinical features of primary hyperparathyroidism include subperiosteal bone resorption, increased serum calcium, decreased phosphate levels, and elevated PTH. Dystrophic calcification is not typically seen in this condition.

Primary hyperparathyroidism is most commonly caused by parathyroid adenoma (75%) and can be localized using sestamibi scan. Kidney stones are the most frequent symptomatic manifestation. It is defined by hypercalcemia with inappropriately normal or elevated PTH.

Associated disorders: peptic ulcers, pancreatitis, bone disease, and CNS symptoms.

Indications for surgery in asymptomatic patients include:

  • Age < 50 years
  • High urinary calcium excretion
  • Low creatinine clearance
  • Kidney stones
  • Very high serum calcium

Reference: Bailey and Love, 27th Edition, Page 826

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