Good Prognostic Factor in Colorectal Cancer MCQ | Left vs Right Colon Cancer
Colorectal Cancer Prognostic Factor MCQ – Left vs Right Colon Cancer
📘 Theme: Colorectal Cancer – Surgical Oncology (NEET SS / INI-CET High Yield)
Colorectal Cancer Prognosis MCQ
Which of the following is considered a good prognostic factor in colorectal cancer?
A. Right-sided tumor
B. Left-sided tumor
C. BRAF positive mutation
D. KRAS positive mutation
Answer: B. Left-sided tumor
Explanation
Left-sided colorectal cancers generally have a better prognosis compared with right-sided tumors. They are more likely to respond to anti-EGFR therapy and are associated with more favorable molecular characteristics.
Right-sided tumors are often associated with microsatellite instability, mucinous histology, and BRAF mutations, which may contribute to poorer outcomes in advanced disease.
Why other options are incorrect
Right-sided tumor: Associated with relatively poorer prognosis and lower response to anti-EGFR therapy.
BRAF positive mutation: BRAF mutation is a poor prognostic marker and is associated with aggressive disease.
KRAS positive mutation: KRAS mutation predicts resistance to anti-EGFR therapy and is not considered a favorable prognostic factor.
High-yield teaching points
Left-sided colon cancers have better overall prognosis than right-sided cancers.
BRAF mutation = poor prognosis in colorectal cancer.
KRAS mutation predicts resistance to cetuximab and panitumumab.
Tumor sidedness has important prognostic and therapeutic implications.