GI Onco

Gall bladder cancer

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Q) True about the presentation of Gall Bladder cancer is ?

a) 50% of the cancers originate in the fundus and body.

b) Nodal disease is present in 1/3 at presentation.

c) Distant metastasis is present is <1/3 of patients at presentation.

d) Acute cholecystitis due to neck mass has worse prognosis.

AIIMS 2017 Questions

Gall bladder MCQS  

Fibrolamellar HCC

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Fibrolamellar HCC MCQ – Liver Tumors – NEET SS Surgery
Q) Fibrolamellar HCC is associated with? ( #NEET Onco Questions 2020)
✅ Correct Answer: a) Young age

🔍 Explanation:
- Fibrolamellar Hepatocellular Carcinoma typically affects younger patients without underlying cirrhosis.
- It is often well-demarcated, encapsulated, and contains a central fibrotic scar.
- Prognosis is better than classic HCC due to higher resectability, absence of chronic liver disease, and a more indolent behavior.
- Long-term survival can be expected in ~50–75% of patients.
- However, lymph node metastasis **can occur**, and when present, is associated with poorer outcomes.

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Prognosis colon cancer

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Good Prognostic Factor in Colorectal Cancer MCQ | Left vs Right Colon Cancer

Colorectal Cancer Prognostic Factor MCQ – Left vs Right Colon Cancer

📘 Theme: Colorectal Cancer – Surgical Oncology (NEET SS / INI-CET High Yield)

Colorectal Cancer Prognosis MCQ

Which of the following is considered a good prognostic factor in colorectal cancer?

A. Right-sided tumor
B. Left-sided tumor
C. BRAF positive mutation
D. KRAS positive mutation

Answer: B. Left-sided tumor

Explanation

Left-sided colorectal cancers generally have a better prognosis compared with right-sided tumors. They are more likely to respond to anti-EGFR therapy and are associated with more favorable molecular characteristics.

Right-sided tumors are often associated with microsatellite instability, mucinous histology, and BRAF mutations, which may contribute to poorer outcomes in advanced disease.

Why other options are incorrect

  • Right-sided tumor: Associated with relatively poorer prognosis and lower response to anti-EGFR therapy.
  • BRAF positive mutation: BRAF mutation is a poor prognostic marker and is associated with aggressive disease.
  • KRAS positive mutation: KRAS mutation predicts resistance to anti-EGFR therapy and is not considered a favorable prognostic factor.

High-yield teaching points

  • Left-sided colon cancers have better overall prognosis than right-sided cancers.
  • BRAF mutation = poor prognosis in colorectal cancer.
  • KRAS mutation predicts resistance to cetuximab and panitumumab.
  • Tumor sidedness has important prognostic and therapeutic implications.

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