Oncosurgery

Renal cell carcinoma

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Q) False about Renal cell carcinoma is

a) More common in males

b) Associated with von hippel lindau syndrome

c) Always require radical nephrectomy

d) Has paraneoplastic manifestaions

Answer

c

Renal cell carcinoma is more common in males

Genetic

loss of heterozygosity in chromosome 3p

B/l RCC is associated with VHL syndrome

Paraneoplastic of RCC

Anemia, hypettension, erythrocytosis.

Radical nephrectomy is the gold standard but not always necessary and partial nephrectomies in selected cases give good clearance

CDH 1 mutation

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Q ) Hereditary diffuse Gastric carcinoma is associated with which  breast cancer
A. Ductal carcinoma NOS subtype
B. Lobular carcinoma
C. DCIS
D. Metaplastic carcinoma

Answer for Q 79

Majority of Gastric Cancers are sporadic,

1–3% of GCs arise as a result of inherited cancer predisposition syndromes.

 Li-Fraumeni syndrome, Lynch syndrome, Peutz-Jeghers syndrome, hereditary breast and ovarian cancer,MUTYH-associated adenomatous polyposis (MAP), familial adenomatous polyposis,  juvenile polyposis syndrome and PTENhamartoma tumour syndrome (Cowden syndrome).

Read on for answer

Glucagonoma

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Q) All are true about Glucagonoma except

a) Usually seen  in middle age and elderly

b) Usually > 5cm at presentation

c) Skin lesions preceed tumor detection by 6-8yrs

d) Often associated with ketoacidosis

Glucaonoma is an endocrine tumor characterized by increased levels of serum glucaogon. It is seen in the age group ............... Read on   (Question 8) 

For other questions on endocrine tumors