Fibrolamellar Carcinoma Liver MCQ – Young Female Liver Tumor
📘 Theme: Liver Tumors – Hepatobiliary Surgery (NEET SS / INI-CET High Yield)
Fibrolamellar Carcinoma MCQ
Which of the following statements regarding fibrolamellar carcinoma of the liver is correct?
A. Occurs in the setting of cirrhosis
B. Has worse survival than hepatocellular carcinoma
C. Can be followed up for long time
D. Seen in young females
Answer: D. Seen in young females
Explanation
Fibrolamellar carcinoma (FLC) is a rare variant of hepatocellular carcinoma that typically affects adolescents and young adults, often females, without underlying cirrhosis or chronic liver disease. Unlike conventional HCC, AFP is usually normal or only mildly elevated.
Histologically, it is characterized by large eosinophilic tumor cells separated by dense lamellar fibrosis.
Why other options are incorrect
Occurs in the setting of cirrhosis: False. FLC usually arises in non-cirrhotic livers.
Has worse survival than hepatocellular carcinoma: False. Fibrolamellar carcinoma generally has better survival than conventional HCC because patients are younger and liver function is preserved.
Can be followed up for long time: False. Surgical resection is the treatment of choice because the tumor has malignant potential.
High-yield teaching points
Young patient + liver mass + no cirrhosis = think fibrolamellar carcinoma.
AFP is often normal in fibrolamellar carcinoma.
Central scar may mimic focal nodular hyperplasia on imaging.