a) It is a humanized monoclonal antibody against VEGF A
b) Bevacizumab is a first-line treatment in metastatic nonsquamous non-small cell lung cancer.
c) Bevacizumab is a first-line or second-line therapy for metastatic colorectal cancer
d) Its major advantage is that it has replaced combination chemotherapy
Correct Answer: d) Its major advantage is that it has replaced combination chemotherapy
Explanation:
a) True – Bevacizumab is a humanized monoclonal antibody targeting vascular endothelial growth factor A (VEGF-A), thereby inhibiting angiogenesis.
b) True – Bevacizumab is used as first-line treatment in combination with chemotherapy for metastatic nonsquamous non-small cell lung cancer (NSCLC).
c) True – Bevacizumab is used as first-line and second-line therapy in combination with chemotherapy for metastatic colorectal cancer.
d) Not true – Bevacizumab is not a replacement for combination chemotherapy. Instead, it is used in combination with standard chemotherapy regimens to improve efficacy. It is not used as a monotherapy in most settings.
Q) In anal carcinoma, involvement of the external iliac lymph nodes indicates which stage of disease according to the AJCC staging system?
a) Stage II
b) Stage IIIA
c) Stage IIIB
d) Stage IV (M1)
Correct Answer: c) Stage IIIB
Explanation:
Primary tumor (T)
TX: primary tumor cannot be assessed
T0: no evidence of primary tumor
Tis: carcinoma in situ (Bowen disease, high-grade squamous intraepithelial lesion [HSIL], anal intraepithelial neoplasia II-III [AIN II-III])
T1: tumor 2 cm or less in greatest dimension
T2: tumor >2 cm but <5 cm in greatest dimension
T3: tumor >5 cm in greatest dimension
T4: tumor of any size invades adjacent organ(s), e.g. vagina, urethra, bladder
(Note: direct invasion of the rectal wall, perirectal skin, subcutaneous tissue, or the sphincter muscle(s) is not classified as T4)
Regional lymph nodes (N)
Nx: regional lymph nodes cannot be assessed
N0: no regional lymph node metastasis
N1: metastasis in regional lymph nodes
N1a: metastases in inguinal, mesorectal, and/or internal iliac lymph nodes
N1b: metastases in external iliac lymph nodes
N1c: metastases in external iliac and in inguinal, mesorectal, and/or internal iliac lymph nodes
Distant metastasis (M)
Mx: distant metastasis cannot be assessed
M0: no distant metastasis
M1: distant metastasis
(Note: involvement of para-aortic or more distant lymph nodes is considered M1)
AJCC Staging:
Stage 0: Tis N0 M0
Stage I: T1 N0 M0
Stage II: T2, T3 N0 M0
Stage IIIA: T1, T2, T3 N1 M0
Stage IIIB: T4 N0/N1 OR T1, T2, T3 with N1b or N1c
Stage IV: Any T, any N, M1
Q) False about intestinal TB? # Gen surgery infections 1. Hyperplastic variety has colonic strictures 2. Raised markers,anaemia,positive sputum culture point towards diagnosis 3. BMFT shows pulled up cecum 4. IFN gamma assay is diagnostic
Ans A) STRICTURES ARE OF SMALL BOWEL
There are two types Of Intestinal TB
Ulcerative type - Transverse ulcers with undermined edges, Serosa of bowel is studded with tubercles. It is a severe form of disease
Hyperplastic - Hyperplasia and thickening of terminal ileum. Narrowing of lumen., Stricture and fibrosis occues of terminal ileum