TIPS

Q) A 60-year-old man with cirrhosis presents with refractory ascites requiring frequent large-volume paracentesis. He is evaluated for TIPS placement. Which of the following findings would be the strongest contraindication to proceeding with the procedure?

A) Serum bilirubin of 3.5 mg/dL
B) MELD score of 18
C) Right heart catheterization showing mean pulmonary artery pressure of 55 mmHg
D) History of prior hepatic encephalopathy controlled on lactulose

#Theme from INI CET GI Mock test Liver

Correct Answer:

C) Right heart catheterization showing mean pulmonary artery pressure of 55 mmHg


Explanation:

  • A mean pulmonary artery pressure >45 mmHg is a contraindication to TIPS due to the risk of worsening right heart failure.

  • Bilirubin up to 3.5 and a MELD score <25 are relative risks but not absolute contraindications.

  • Prior controlled hepatic encephalopathy is not a strict contraindication, though the risk of recurrence post-TIPS is higher.

  • TIPS is often used in patients with refractory ascites when medical management fails.

Malignancy risk in Stem cells

Q) Risk of malignancy is highest with which stem cells. # Bailey Chapter 4 

#Theme from INI CET GI Mock test

a) Somatic cells

b) SSc

c) Fetal cells

d) All

Giant cell tumor femur

Q) A 22-year-old woman presents with a giant cell tumor (GCT) of the distal
femur. Appropriate treatment would be: ( theme from test 13 on 31/3/24) 

A. Curettage and debridement.
B. Amputation.
C. Radiation.
D. Preoperative chemotherapy, resection, and adjuvant chemotherapy.

Parkland formula

Q )  During fluid resuscitation in a burns patient using Parkland’s formula, volume of fluid given in first 8 hours is ?
A. 50%
B. 25 % 
C. 75 % 
D. 100 % 

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Ans a

The modified Parkland formula

TBSA% burn × weight (kg) × 4 = volume in mL
The first half is given in 8 hours and the second over 16 hours to complete the 24-hour resuscitation time frame.

Developed by Dr. Charles Baxter in the 1960s at the Parkland Memorial Hospital in Texas, this formula serves as a cornerstone in determining the initial fluid requirements to stabilize burn victims during the crucial early hours following injury.

Although the Parkland Formula offers a valuable framework for fluid resuscitation, it's important to note that individual patient variability, coexisting injuries, and evolving clinical conditions necessitate close monitoring and adjustment of the resuscitation plan. Over-resuscitation can lead to complications such as pulmonary edema, while under-resuscitation can result in inadequate tissue perfusion and organ failure.

Bailey 28th  671
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