Q) All are true regarding perioperative management Of IBD on steroid except
a) Minor procedure needs only routine steroidal dose supplementation b) Major procedures needs Hydrocort 100-150 mg tds 3.Chronic steroid use causing adrenal failure that presents with hypotension, vomiting, fever, lethargy 4.All cases of UC need supraphysiological dose of steroid.
Q: Which of the following is NOT a risk factor for pouchitis post-IPAA in ulcerative colitis?
Explanation Ans A :
Pouchitis is a common complication of Ileal Pouch Anal Anastomosis (IPAA) for Ulcerative Colitis, with an incidence up to 50%.
✅ Smoking is protective against pouchitis.
Risk factors include:
- Extra-intestinal manifestations (e.g. arthritis)
- ANCA positivity
- NOD2insC mutation
- NSAIDs and PPI use post-op
- Extent of colitis and thrombocytosis
In radiation proctitis, surgery is typically indicated for complications that are severe or unmanageable through conservative measures. The options can be considered as follows:
A) Pain Abdomen: While abdominal pain can be a symptom associated with radiation proctitis, it is not an indication for surgery on its own. Pain management and other conservative treatments can be employed first.
B) Rectal stricture: This can cause significant obstruction and may require surgical intervention to restore normal bowel function.
C) Haemorrhage: Severe bleeding due to radiation proctitis may necessitate surgical intervention if it is not controlled by endoscopic or conservative measures.
D) Vesical Fistula: The formation of a fistula between the bladder and rectum (vesical fistula) is a serious complication that often requires surgical repair.
Acute Radiation proctitis - Occurs within 6 mths of starting the treatment
Chronic - After 6 mths, Most patients develop symptoms at a median of 8 to 12 months after completion of radiotherapy
Modified Radiation Therapy Oncology Group rectal toxicity scale
Grade 1
Mild and self-limiting
Minimal, infrequent bleeding or clear mucus discharge, rectal discomfort not requiring analgesics, loose stools not requiring medications
Grade 2
Managed conservatively, lifestyle (performance status) not affected
Intermittent rectal bleeding not requiring regular use of pads, erythema of rectal lining on proctoscopy, diarrhea requiring medications
Grade 3
Severe, alters patient lifestyle
Rectal bleeding requiring regular use of pads and minor surgical intervention, rectal pain requiring narcotics, rectal ulceration
Use of newer conformal radiation therapy techniques.
Amifostine is a prodrug that is metabolized to a thiol metabolite that is thought to scavenge reactive oxygen species
Placebo-controlled phase III trials have detected no benefit from either topical or oral sucralfate.
Treatment of radiation proctitis
Medical
Butyrates
ASA
Sucralfate
Metronidazole
Short chain FA
Topical formalin
Hyperbaric o2
Endoscopic
dilatation
Heater and bipolar cautrey
ND YAG
APC
RFA
Surgery
Diverting ostomies for severe stricture - Better for incontinence, stricture and limited benefit for bleed
Reconstruction with Flaps - rectourethral or rectovaginal fistula with a pedunculated gracilis or a Martius flap to facilitate healing by introducing well-vascularized healthy tissue,
Proctectomy complicated fistulous disease, especially when accompanied by significant pain and incontinence, or in cases of severe and intractable bleeding