Necrotising Infections

MCQ on Necrotizing Infections
Q) Least common Signs or symptoms of necrotising infections is
Answer: D. Fever

🔍 Explanation:
**Fever is usually absent** in necrotizing infections.

Indicators of Necrotizing Infections include:
- **Severe and Unusual Pain**: Patients often report intense pain disproportionate to the visible injury.
- **Swelling Beyond the Redness**: Edema extends past the erythema, signaling deeper tissue involvement.
- **Presence of Crepitus**: A crackling sound or sensation beneath the skin caused by gas-producing bacteria.
- **Formation of Blisters**: Skin blisters indicate significant tissue damage.
- **Dishwater-like Drainage**: The infected site may discharge greyish, watery fluid, resembling dishwater.
- **Discoloration of Skin**: Pink or orange staining in the skin indicates infection severity.
- **Localized Skin Necrosis**: Late-stage gangrene may develop in the skin.

**Systemic Complications** may include shock, coagulopathy, and multi-organ failure as the infection advances.

🧠 Key Point: While fever is a hallmark of most infections, it is often notably absent in necrotizing infections, which can be a distinguishing factor.

📘 Reference: MCQs on Infections (Bailey and Sabiston)

MCQ on Abdominal compartment Syndrome

Q) Which of the following is true for abdominal compartment syndrome?

a) Normal Intra Abdominal pressure ( IAP) is 5-7 mm Hg

b) Laparotomy is needed if IAP is more than 10 mmHg

c) Vascular compromise occurs is IAP is more than 15 mmHg

d) Increased IAP increases increased systemic vascular resistance ( SVR)  

PET CT In Urological Malignancies

Q) PET CT in urological  malignancies most useful in? ( Questions as per NEW NEET SS Pattern) 

a) RCC

b) Testis

c) Urinary bladder

d) all

Ans B

Testis

In men with testis cancer, it is recommended in the follow-up of patients with seminoma with any residual mass

Promising in Urinary bladder ca

Not used in RCC 

BAiley page 1391

Differential diagnosis of mass in right iliac fossa

Q) Patient with generalized ill health and pyrexia has a mass in the right iliac fossa with a history of blood-stained mucoid diarrheia? Most common etiology in this case would be ? 

a) Carcinoma

b) TB

c) Amoeboma

d) Lymphoma

More questions on general surgery tropical infections

Ans  c

Amoeboma is partially treated amoebic infection of the caecum

It mostly presents as a mass in RIF and causes confusion with malignancy.

Such a patient is highly unlikely to have a carcinoma because altered bowel habit is not a feature of right-sided colonic carcinoma.

Ref Bailey page 58

Statistics – Tests of significance

Q) To Study the effect of an antiviral  drug, we note down the initial viral load and then after  a month repeat viral load. What is the   the most appropriate statistical test of significance to test the change in viral load

(a) Paired t-test
(b) Unpaired or independent t-test
(c) Analysis of variance
(d) Chi-square test

Ans a) Paired t test

paired t test is used When comparing the same person results after giving a drug or doing a surgery or any intervention

A paired t-test is used when we are interested in the difference between two variables for the same subject. Often the two variables are separated by time

Unpaired t test

The unpaired two-samples t-test is used to compare the mean of two independent groups.

For example, suppose that we have measured the weight of 100 individuals: 50 women (group A) and 50 men (group B). We want to know if the mean weight of women  is significantly different from that of men In this case, we have two unrelated (i.e., independent or unpaired) groups of samples. Therefore, it’s possible to use an independent t-test to evaluate whether the means are different.

Chi-square test

The basic idea behind the test is to compare the observed values in your data to the expected values that you would see if the null hypothesis is true.

To determine whether the association between two qualitative variables is statistically significant

Analysis of Variance ANOVA example

A group of psychiatric patients are trying three different therapies: counseling, medication and biofeedback. You want to see if one therapy is better than the others.

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