Oncosurgery

Wilms tumor

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Q) All are true of Wilms tumor except

a) Surgery is the mainstay of treatment

b) Associated with favorable and unfavorable histology

Fibrolamellar HCC

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Q) Fibrolamellar HCC is associated with ? ( #NEET onco Questions 2020) 

a) Young age

b) No lymph node metastasis

c) Poor Prognosis

d) Occurs in setting of cirrhosis

Ans a

Young age

This tumor generally occurs in younger patients without a history of cirrhosis.

Well demarcated and encapsulated and may have a central fibrotic scar

Good prognosis than HCC, probably related to high resectability rates, lack of chronic liver disease, and a more indolent course. Long-term survival can be expected in approximately 50% to 75%

Lymph nodes can be involved and associated with poor outcome

 

Genes and Cancers

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In This post I will be adding most commonly associated genetic abnormalities and changes

MEN2 syndrome is caused by gain of function mutations in the RET  gene.

Li-Fraumeni syndrome is associated with mutation of P53.

Mutations in p16 is associated with melanomas, pancreas, esophagus, head and neck, stomach, breast, and colon.

BRCA1 is associated with breast and ovarian carcinoma. 

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