MCQ on General onco

MCQ on Mechanisms of Cancer Cells Invasion
Q) Which is not a mechanism of cancer cells invasion?
Answer: D. Extracellular matrix dissolution is due to physical factors

🔍 Explanation:
Cancer cells secrete collagenases and proteases that chemically dissolve extracellular boundaries to facilitate invasion.
The three main mechanisms by which cancer cells invade are:
- **Dissolution of Extracellular Matrix**: Cancer cells secrete enzymes like matrix metalloproteinases (MMPs) that break down the extracellular matrix, allowing for tissue penetration.
- **Acquisition of Mobility**: Cancer cells undergo changes in their adhesion properties and cytoskeleton, which allows them to move through tissues.
- **Rise in Interstitial Pressure**: Although this may affect fluid dynamics, it is a consequence of tumor growth, not a direct invasion mechanism.

🧠 Key Point: The dissolution of the extracellular matrix is a chemical process, not due to physical factors like pressure.

Fibrolamellar HCC

Fibrolamellar HCC MCQ – Liver Tumors – NEET SS Surgery
Q) Fibrolamellar HCC is associated with? ( #NEET Onco Questions 2020)
Correct Answer: a) Young age

🔍 Explanation:
- Fibrolamellar Hepatocellular Carcinoma typically affects younger patients without underlying cirrhosis.
- It is often well-demarcated, encapsulated, and contains a central fibrotic scar.
- Prognosis is better than classic HCC due to higher resectability, absence of chronic liver disease, and a more indolent behavior.
- Long-term survival can be expected in ~50–75% of patients.
- However, lymph node metastasis **can occur**, and when present, is associated with poorer outcomes.

👉 Explore more Liver MCQs

Genes and Cancers

In This post I will be adding most commonly associated genetic abnormalities and changes


MEN2 syndrome is caused by gain of function mutations in the RET  gene.

Li-Fraumeni syndrome is associated with mutation of P53.

Mutations in p16 is associated with melanomas, pancreas, esophagus, head and neck, stomach, breast, and colon.

BRCA1 is associated with breast and ovarian carcinoma.