MCQ on General onco

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MCQ on Mechanisms of Cancer Cells Invasion
Q) Which is not a mechanism of cancer cells invasion?
✅ Answer: D. Extracellular matrix dissolution is due to physical factors

🔍 Explanation:
Cancer cells secrete collagenases and proteases that chemically dissolve extracellular boundaries to facilitate invasion.
The three main mechanisms by which cancer cells invade are:
- **Dissolution of Extracellular Matrix**: Cancer cells secrete enzymes like matrix metalloproteinases (MMPs) that break down the extracellular matrix, allowing for tissue penetration.
- **Acquisition of Mobility**: Cancer cells undergo changes in their adhesion properties and cytoskeleton, which allows them to move through tissues.
- **Rise in Interstitial Pressure**: Although this may affect fluid dynamics, it is a consequence of tumor growth, not a direct invasion mechanism.

🧠 Key Point: The dissolution of the extracellular matrix is a chemical process, not due to physical factors like pressure.

PET CT In Urological Malignancies

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Q) PET CT in urological  malignancies most useful in? ( Questions as per NEW NEET SS Pattern) 

a) RCC

b) Testis

c) Urinary bladder

d) all

Ans B

Testis

In men with testis cancer, it is recommended in the follow-up of patients with seminoma with any residual mass

Promising in Urinary bladder ca

Not used in RCC 

BAiley page 1391

Differential diagnosis of mass in right iliac fossa

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Q) Patient with generalized ill health and pyrexia has a mass in the right iliac fossa with a history of blood-stained mucoid diarrheia? Most common etiology in this case would be ? 

a) Carcinoma

b) TB

c) Amoeboma

d) Lymphoma

More questions on general surgery tropical infections

Ans  c ✅

Amoeboma is partially treated amoebic infection of the caecum

It mostly presents as a mass in RIF and causes confusion with malignancy.

Such a patient is highly unlikely to have a carcinoma because altered bowel habit is not a feature of right-sided colonic carcinoma.

Ref Bailey page 58

Vascular occlusion ( MCQ with free answer)

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Q) During hepatic resection, there was excessive bleeding and Pringle's maneuvre was performed. What is false about vascular occlusion for hepatic surgery?

A. Portal triad clamping along with clamping of supra hepatic and infra hepatic IVC allows adequate bleeding control
B. Prolonged intermittent clamping is usually used in longer surgeries
C. Portal triad clamping can be done for 60 minutes under normothermia
D. Liver tolerates vascular clamping well

Ans b is false, Short intermittent clamping is better

Hepatic vascular exclusion (HVE) combines total inflow and outflow vascular occlusion of the liver. Total isolation of the liver
from the systemic circulation is intended during resection of large tumors adjacent to or involving the major hepatic veins
and/or the IVC.  ( BG 1619)

Intermittent inflow occlusion (Pringle, 1908) to control blood flow to the remnant, usually maintaining inflow occlusion for
periods of 15 minutes, interspersed by 5 minute periods of relief to allow perfusion of the remnant and decompression of
the bowel.

The superiority of intermittent inflow occlusion versus continuous or total occlusion is now widely accepted

According to the Cochrane database, in elective resection, intermittent portal triad clamping seems better than continuous clamping, especially in patients with diseased parenchyma. Therefore, intermittent triad clamping could be recommended as the “gold
standard” method of clamping

Clamps are applied for up to 60 minutes in patients with normal liver ( BG 1619)

c)  is true A number of studies have

established that ≤ 90 min of complete PTC is safe in normal livers. Nonetheless, many surgeons will not clamp the inflow continuously for > 45 min because of concern about occult liver damage and most resections can be accomplished within this time frame.

d) is true Although the liver is relatively resistant to periods of warm ischaemia, it is vulnerable to anoxic conditions and may be more severely vulnerable if it has been chronically damaged by either cirrhosis or chemotherapy.